Since the 1970s, indole-3-carbinol (I3C), a compound found in broccoli, has been studied for its anti-tumor activity. New work shows it enhances the diversity of the mouse microbiome, reduces levels of a toxic metabolite from meat (TMAO), and protects mice from atherosclerosis (50–100 mg/kg body weight/day). Super interesting 🤔
tinyurl.com
tinyurl.com
I3C triggers DNA repair, cell-cycle arrest, apoptosis, disruption of cell migration, and modulates hormone receptor signaling
Bioactive compounds are made when cruciferous vegetables known as glucosinolates are stressed. An example is glucobrassicin. When cruciferous vegetables like broccoli, Brussels sprouts, and cabbage are chopped or chewed, the enzyme myrosinase converts glucobrassicin into I3C, which has a sulfurous, cabbage-like odor mdpi.com
Here is paper on the effects of I3C on cell signaling & cancer. While most of the work has been in mice, human clinical trials testing the effects on human tumor progression are in progress cancerci.biomedcentral.com
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