Triple-Negative #Breast_Cancer (TNBC)
Defined as a unique and aggressive subtype of #breast_cancer, characterized by the absence of estrogen (ER) and progesterone (PR) receptors and HER2 protein. Here's what you should know:
#BreastCancer #Genomics #breastcancerawareness
Defined as a unique and aggressive subtype of #breast_cancer, characterized by the absence of estrogen (ER) and progesterone (PR) receptors and HER2 protein. Here's what you should know:
#BreastCancer #Genomics #breastcancerawareness
1. Why Is It Important?
1.1 TNBC accounts for 10-20% of #breast_cancer cases and is often diagnosed in younger women.
1.2 It progresses faster and has fewer treatment options compared to other subtypes.
1.1 TNBC accounts for 10-20% of #breast_cancer cases and is often diagnosed in younger women.
1.2 It progresses faster and has fewer treatment options compared to other subtypes.
2. #Genomic Features of TNBC:
2.1 Strong association withΒ #BRCA1 #mutationsΒ and genomic instability.
2.2 High mutational burden, which makes it a potential candidate for #immunotherapy.
2.1 Strong association withΒ #BRCA1 #mutationsΒ and genomic instability.
2.2 High mutational burden, which makes it a potential candidate for #immunotherapy.
3. Challenges in Treatment:
3.1 Hormonal and HER2-targeted therapies donβt work.
3.2 #Chemotherapy is the strength, but newer genomic #approaches like PARP inhibitors and immune checkpoint inhibitors are promising.
3.1 Hormonal and HER2-targeted therapies donβt work.
3.2 #Chemotherapy is the strength, but newer genomic #approaches like PARP inhibitors and immune checkpoint inhibitors are promising.
4. Why Genomics Matters:
4.1 Genomic profiling helps classify mutations and guide #personalized treatments.
4.2 Future #research focuses on using genomics to improve #early_diagnosis and outcomes.
4.1 Genomic profiling helps classify mutations and guide #personalized treatments.
4.2 Future #research focuses on using genomics to improve #early_diagnosis and outcomes.
Please note that all information provided is based on scientific research and is not intended as official medical advice or a substitute for recommendations from a licensed doctor or specialist.
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