1/ Do you know what a mixing study is? Let's take you through some important facts. A short🧵
2/ A mixing study involves mixing patient plasma with normal plasma. It helps in the first stage of investigating a prolonged APTT 👇
If you have an unexplained and isolated APTT and no heparin, think of haemophilia. Mixing studies can help in the diagnostic pathway.
If you have an unexplained and isolated APTT and no heparin, think of haemophilia. Mixing studies can help in the diagnostic pathway.
3/ However, be careful
🔴Most inhibitors detected in acquired haemophilia A (AHA) are heat & time-dependent. Hence mixing studies require incubation for 2 hours.
🔴Most inhibitors detected in acquired haemophilia A (AHA) are heat & time-dependent. Hence mixing studies require incubation for 2 hours.
4/🔴In AHA, mixing studies tested immediately are likely similar to those seen in patients with a single factor deficiency & no inhibitor.
🔴Mixing studies are also poorly standardised, limiting the comparison of results between laboratories.
🔴Mixing studies are also poorly standardised, limiting the comparison of results between laboratories.
5/ Key message
Further investigation is always required, and factor activity assays should be performed in parallel with mixing studies to facilitate early diagnosis, especially in acquired and congenital haemophilia.
Reference: bit.ly
Further investigation is always required, and factor activity assays should be performed in parallel with mixing studies to facilitate early diagnosis, especially in acquired and congenital haemophilia.
Reference: bit.ly
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