1/ What is the optimal timing of #intubation in critically ill patients?
✔️International multicenter study
✔️COVID-19 pts, 10 academic institutions, US & Europe
✔️Severity criteria/group
👉Early: SOFA<7 or P/F ratio>250
👉Late: SOFA≥7 and P/F ratio≤250
pubmed.ncbi.nlm.nih.gov
✔️International multicenter study
✔️COVID-19 pts, 10 academic institutions, US & Europe
✔️Severity criteria/group
👉Early: SOFA<7 or P/F ratio>250
👉Late: SOFA≥7 and P/F ratio≤250
pubmed.ncbi.nlm.nih.gov
2/ 🧐
✔️Complex statistical methodology that offers an alternative approach to estimating causal effects without conducting RCTs
✔️Important when conducting RCTs for various reasons, such as the current pandemic's evolving nature, is not possible or ethical
✔️Complex statistical methodology that offers an alternative approach to estimating causal effects without conducting RCTs
✔️Important when conducting RCTs for various reasons, such as the current pandemic's evolving nature, is not possible or ethical
3/
🔥Lower risk of 30-day mortality in those intubated at a stage of less severe organ dysfunction (early group)
🔥The association held irrespective of the timing of intubation relative to hospital admission
🔥The covid surge did not affect the primary outcome
🔥Lower risk of 30-day mortality in those intubated at a stage of less severe organ dysfunction (early group)
🔥The association held irrespective of the timing of intubation relative to hospital admission
🔥The covid surge did not affect the primary outcome
4/
Intubation timing aligned with severity criteria & conducted when physiological reserve is relatively⬆️ may be associated with better survival outcomes
@salimhayek @jespereugen @yiyuan_huang @JochenReiser @GarciaGuadiana
#CritCareMed #MedTwitter #FOAMed
@SCCM @ESAIC_org @ESICM
Intubation timing aligned with severity criteria & conducted when physiological reserve is relatively⬆️ may be associated with better survival outcomes
@salimhayek @jespereugen @yiyuan_huang @JochenReiser @GarciaGuadiana
#CritCareMed #MedTwitter #FOAMed
@SCCM @ESAIC_org @ESICM
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