Images of Infectious Diseases
#MayoIDCase
This is a challenging case of an immunosuppressed person with mental and behavioral changes. Imaging studies showed a large mass lesion in the brain. Histopathology is shown (GMS stain).
#MayoIDCase
This is a challenging case of an immunosuppressed person with mental and behavioral changes. Imaging studies showed a large mass lesion in the brain. Histopathology is shown (GMS stain).
2/
Case continued:
Neurosurgical evacuation of the brain abscess was performed. GMS showed hyphae. Culture: Lomentospora prolificans. Which of the following antifungal drugs is most likely an effective treatment?
Case continued:
Neurosurgical evacuation of the brain abscess was performed. GMS showed hyphae. Culture: Lomentospora prolificans. Which of the following antifungal drugs is most likely an effective treatment?
3/
#Lomentospora prolificans is an emerging cause of serious invasive fungal infections. It is notable for its multi drug resistant pattern.
Optimal Rx is unknown, but #voriconazole-containing regimens are considered the treatment of choice.
#Lomentospora prolificans is an emerging cause of serious invasive fungal infections. It is notable for its multi drug resistant pattern.
Optimal Rx is unknown, but #voriconazole-containing regimens are considered the treatment of choice.
4/
#Lomentospora prolificans
Combination antifungal Rx was associated with increased 28-day survival
The combination of #voriconazole plus #terbinafine trended to be associated with higher rates of treatment success
doi.org
#Lomentospora prolificans
Combination antifungal Rx was associated with increased 28-day survival
The combination of #voriconazole plus #terbinafine trended to be associated with higher rates of treatment success
doi.org
5/
#Lomentospora prolificans
Among novel drugs, the most promising is #Olorofim. Olorofim inhibits fungal dihydroorotate dehydrogenase and possess in vitro activity vs Penicillium, Fusarium, Aspergillus, Scedosporium, Lomentospora, and rare molds.
doi.org
#Lomentospora prolificans
Among novel drugs, the most promising is #Olorofim. Olorofim inhibits fungal dihydroorotate dehydrogenase and possess in vitro activity vs Penicillium, Fusarium, Aspergillus, Scedosporium, Lomentospora, and rare molds.
doi.org
Loading suggestions...