Anti-acidity medicines increase the risk of heart attacks
1. Proton pump inhibitors (PPIs) like omeprazole, esomeprazole & rabeprazole are commonly used for treating GERD and other acidity-related disorders.
A recent study looked at long-term PPI use and risk of heart diseases.
1. Proton pump inhibitors (PPIs) like omeprazole, esomeprazole & rabeprazole are commonly used for treating GERD and other acidity-related disorders.
A recent study looked at long-term PPI use and risk of heart diseases.
2. 19,229 adults with type 2 diabetes were followed up for about 11 years.
Long term PPI users had 27% higher risk of coronary artery disease; 34% higher risk of myocardial infarction, 35% higher risk of heart failure & 30% higher risk of all-cause death, as compared to non-users
Long term PPI users had 27% higher risk of coronary artery disease; 34% higher risk of myocardial infarction, 35% higher risk of heart failure & 30% higher risk of all-cause death, as compared to non-users
3. The mechanism of PPI increasing the risk of #heart diseases could be: the effects of PPI on altering gut microbes and their interaction with anti-platelet agents (PPIs may reduce the bio-availability of clopidogrel).
#MedTwitter #Gastroenterology #gerd
#MedTwitter #Gastroenterology #gerd
4. Take home message
*Long-term use of PPIs should be discouraged.
*Patients taking PPIs for long duration should discuss the risk: benefit ratio with the doctor.
*This is observational data showing association; can not prove cause & effect.
Reference
doi.org
*Long-term use of PPIs should be discouraged.
*Patients taking PPIs for long duration should discuss the risk: benefit ratio with the doctor.
*This is observational data showing association; can not prove cause & effect.
Reference
doi.org
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