1/🧵Our speed in understanding Long COVID is accelerating‼️
Here I cover a smorgasbord of recent COVID data on…
📍Brain Aging
📍Genetics
📍Epidemiology
📍PEM
📍Self-Protection
Knowledge is Power.
We are all at risk of losing Brain Power from #LongCOVID.
Let’s learn…
Here I cover a smorgasbord of recent COVID data on…
📍Brain Aging
📍Genetics
📍Epidemiology
📍PEM
📍Self-Protection
Knowledge is Power.
We are all at risk of losing Brain Power from #LongCOVID.
Let’s learn…
2/ COVID ages our brains 😫
Cognitive decline is part of growing old, but this is scary.
Hot new data w age-matched uninfected control ICU patients show how COVID is associated w Molecular Signatures of an Aging Brain.
See Fig 2 a/b/c BELOW
go.nature.com
Cognitive decline is part of growing old, but this is scary.
Hot new data w age-matched uninfected control ICU patients show how COVID is associated w Molecular Signatures of an Aging Brain.
See Fig 2 a/b/c BELOW
go.nature.com
3/ Genetics
This study included normal controls. Gene expression changes occur during acute COVID19 in hospital that are associated w subsequent LongCOVID.
This was especially seen in antibody producing Plasma Cells, which explained symptom clusters.
go.nature.com
This study included normal controls. Gene expression changes occur during acute COVID19 in hospital that are associated w subsequent LongCOVID.
This was especially seen in antibody producing Plasma Cells, which explained symptom clusters.
go.nature.com
4/ The BRAIN…it’s “so much more than its constituent cells. Each neuron connects with thousands of other neurons—and instead of a cacophony of connections, we have a synchronized symphony.
Until it’s NOT a symphony…as in #LongCOVID brain fog
bit.ly
Until it’s NOT a symphony…as in #LongCOVID brain fog
bit.ly
6/ Many regions are experiencing an upsurge of Covid infections right now.
Follow leaders like @Bob_Wachter who update us regularly and make your risk/benefit behavior decisions.
Keep reading…more data👇
Follow leaders like @Bob_Wachter who update us regularly and make your risk/benefit behavior decisions.
Keep reading…more data👇
7/ Epidemiology - UK
🔹33k COVID vs 63k controls followed 1.5 yrs
🔹6% of COVID patients had not recovered
🔹Predictors of non-recovery included hospitalization, female, lung dz, older age, depression
💥Vaccination assoc w reduced symptoms in 7 domains
go.nature.com
🔹33k COVID vs 63k controls followed 1.5 yrs
🔹6% of COVID patients had not recovered
🔹Predictors of non-recovery included hospitalization, female, lung dz, older age, depression
💥Vaccination assoc w reduced symptoms in 7 domains
go.nature.com
9/ We’ll need to rethink & retest approaches typical for physical & cognitive rehabilitation from usual ICU illness (#PICS) vs #LongCOVID due to realities of PEM/PESE.
Could this profound “fatigue” be due to widespread changes in mitochondrial biology?
bit.ly
Could this profound “fatigue” be due to widespread changes in mitochondrial biology?
bit.ly
11/ Mechanisms of Long COVID
LC brain & body disease may be caused by multiple mechanisms. These are reviewed well by @michelle_monje @VirusesImmunity ❤️
In the next tweets, I offer 5 different scenarios being considered…beware LOTS of overlaps likely
bit.ly
LC brain & body disease may be caused by multiple mechanisms. These are reviewed well by @michelle_monje @VirusesImmunity ❤️
In the next tweets, I offer 5 different scenarios being considered…beware LOTS of overlaps likely
bit.ly
12/ Mechanism & Possible Treatment for Long COVID: 1
Ongoing viral replication (SARS-CoV-2 or EBV or CMV or other) which causes apro-inflammatory injury responses whereby at least antivirals are needed +/- immune modulation
Ongoing viral replication (SARS-CoV-2 or EBV or CMV or other) which causes apro-inflammatory injury responses whereby at least antivirals are needed +/- immune modulation
16/ LC Mechanism & Possible Treatment: 5
A primary endothelial disease now exists leading to micro-clots & downstream hypoxemia / cell death and even angiogenesis.
See 🧵👇
A primary endothelial disease now exists leading to micro-clots & downstream hypoxemia / cell death and even angiogenesis.
See 🧵👇
20/ Summary
Long COVID is a real syndrome occurring in the bodies of millions related to different types of pathology.
People are left w profound disability to exercise physically & mentally.
Support, validation, science, and robust preventive measures are in high demand.
Long COVID is a real syndrome occurring in the bodies of millions related to different types of pathology.
People are left w profound disability to exercise physically & mentally.
Support, validation, science, and robust preventive measures are in high demand.
Updated news on Vaccine science…
We really need to act quickly in pursuing next generation COVID Vaxx as the virus continues to emerge its immune evasion stealth.
See op-ed H/T @DrEricDing
bit.ly
We really need to act quickly in pursuing next generation COVID Vaxx as the virus continues to emerge its immune evasion stealth.
See op-ed H/T @DrEricDing
bit.ly
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