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COVID-19 Vaccines
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Vaccine Efficacy
Delta variant
💡BREAKING—CDC study confirms the NIH-Moderna #COVID19 vaccine is more effective against #DeltaVariant hospitalizations than Pfizer-BioNTech or Johnson & Johnson. Vaccine efficacy for Delta🏥—Moderna 95%, Pfizer 80%, J&J 60%. VE also higher in age <74!🧵
cdc.gov
cdc.gov
2) “Overall, VE against COVID-19 hospital- ization was 86%. VE was significantly lower among adults aged ≥75 years (76%) than among those aged 18–74 years (89%) (Table). The difference in VE point estimates between age groups was similar for Pfizer-BioNTech and Moderna vaccines”
3) “Across all ages, VE was significantly higher among Moderna vaccine recipients (95%) than among Pfizer-BioNTech (80%) or Janssen (60%) vaccine recipients.”
4) Is this difference also true for ER visits too? Yes. For ER—“VE was highest among Moderna vaccine recipients (92%), followed by Pfizer-BioNTech vaccine recipients (77%), and was lowest (65%) for Janssen vaccine recipients (Table).”
5) What about all breakthrough infections? Well, CDC itself doesn’t track all cases nationwide. But luckily, Oklahoma tracks breakthroughs by vaccine type - and in this other report, Moderna also had the lowest vaccine breakthrough rates for total infections!
6) Show more proof? Moderna also produced 2.6x more antibodies against the #SARSCoV2 virus than Pfizer in another Belgian study! We think this is because Moderna’s standard dose is 100 microgram while Pfizer’s is 30 mcg. Many scientists acknowledge this + Moderna longer time gap.
7) Another study from Minnesota found an even bigger difference between Moderna and Pfizer… for breakthroughs, ➡️ Moderna had HALF as many breakthrough infections as Pfizer! Look at the graph!
8) Let’s still remember unvaccinated are still 11x more likely to die of #COVID19. Thus, any vaccine is still leaps and bounds better than no vaccine. washingtonpost.com
9) Moderna is also developing 4 variant adapted variant-specific spike vaccines! One for #DeltaVariant, one for #BetaVariant, one for Beta+Delta, and one for Beta+original!
seekingalpha.com
seekingalpha.com
10) Where else have we seen fewer breakthroughs with Moderna? DC health department also noticed it a month ago… much much lower than J&J, and somewhat lower than Pfizer.
It’s been an active debate for a while—but the clue were all there for us epidemiologists watching closely.
It’s been an active debate for a while—but the clue were all there for us epidemiologists watching closely.
11) Moderna 3rd shot booster’s EUA is obviously coming soon. But there is a bug debate whether to EUA authorize it as a full standard 100 mcg dose or to cut it to 50 mcg dose for the booster. I hope 100 mcg! google.com
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