Fascinating #hemepath and #flowcytometry case that I learned something new! Sharing to spread the 🧠.
Adult, with leukocytosis & splenomegaly. You get morphology and the flow.
What do you think?
- TALL vs mature lymphoma?
- Explanation for TCR
- Can you predict genetics?
Adult, with leukocytosis & splenomegaly. You get morphology and the flow.
What do you think?
- TALL vs mature lymphoma?
- Explanation for TCR
- Can you predict genetics?
Well, #pathtwitter remains undefeated and, as expected, everyone is awesome!
This is indeed a GD T-ALL (ETP immunophenotype) with t(10;11) PICALM-MLLT10 rearrangement
I learned that this rearrangement causes GD T-cell maturation arrest! That explains the TCR and sCD3 here.
This is indeed a GD T-ALL (ETP immunophenotype) with t(10;11) PICALM-MLLT10 rearrangement
I learned that this rearrangement causes GD T-cell maturation arrest! That explains the TCR and sCD3 here.
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