Just published @CellCellPress: From 60 patients convalesced from #COVID19, single-cell sequencing of their B cells-> 14 potent neutralizing monoclonal antibodies. With 1 #3D crystal structure, and model efficacy in hACE2 mice as preventive therapy. Wow.👍
cell.com
cell.com
There have been 2 prior reports (both @ScienceMagazine) isolating neutralizing antibodies, each from a single patient w/discovery of key epitopes +cryo-EM structure. This report goes well beyond those w/ sc-RNA seq of B cells *60* patients, model efficacy, best nAb paper to date
Here are the links to the 2 prior @ScienceMagazine papers:
science.sciencemag.org
science.sciencemag.org
This work will accelerate nAbs and vaccine devp't.
I think nAbs have the best short term shot for making an Rx difference
science.sciencemag.org
science.sciencemag.org
This work will accelerate nAbs and vaccine devp't.
I think nAbs have the best short term shot for making an Rx difference
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