I have been working with #ivermectin for more than 10 years.
We need to talk about ivermectin and #COVID19
Thread ?
We need to talk about ivermectin and #COVID19
Thread ?
#SARS_COV_2 is a positive single-stranded RNA virus
Ivermectin inhibits in vitro the replication of several positive single-stranded RNA viruses such as:
- Dengue
- Zika
- Chikungunya
- Yellow Fever
Ivermectin inhibits in vitro the replication of several positive single-stranded RNA viruses such as:
- Dengue
- Zika
- Chikungunya
- Yellow Fever
The new in vitro data from Caly et al. Show 50% inhibition of #SARS_COV_2 replication after incubating VERO cells with 2.8 uM for 2 days.
How much is 2.8 uM Carlos?
That is a good question.
sciencedirect.com
How much is 2.8 uM Carlos?
That is a good question.
sciencedirect.com
2.8 uM is the equivalent of a plasma concentration of 2100 ng/ml.
Lets put that into perspective.
The ivermectin dose used for river blindness is 200 mcg/kg. That is one tablet of 3 mg for every 15 kg of weight.
malariajournal.biomedcentral.com
Lets put that into perspective.
The ivermectin dose used for river blindness is 200 mcg/kg. That is one tablet of 3 mg for every 15 kg of weight.
malariajournal.biomedcentral.com
The maximum plasma concentration reached with that dose is around 40 ng/ml.
That is 50-fold less that the concentration proven to cut viral replication in half.
There is however hope. Prove antiviral activity opens the door to carefully conducted and controlled trials.
That is 50-fold less that the concentration proven to cut viral replication in half.
There is however hope. Prove antiviral activity opens the door to carefully conducted and controlled trials.
Now, if you are considering using ivermectin on a compassionate basis you must know this:
Ivermectin can cross react with GABA-gated chlorine channels in the CNS and cause neurotoxicity. This is normally prevented by the blood bran barrier (BBB), particularly by the P-gp.
Ivermectin can cross react with GABA-gated chlorine channels in the CNS and cause neurotoxicity. This is normally prevented by the blood bran barrier (BBB), particularly by the P-gp.
If you do not have a fully functional BBB ivermectin may not be the safe drug it usually is.
Now, hyperimflammatory states, such as the one caused by #COVID19 make the BBB leaky.
I would be careful to use ivermectin in severely ill patients with proven efficacy.
Now, hyperimflammatory states, such as the one caused by #COVID19 make the BBB leaky.
I would be careful to use ivermectin in severely ill patients with proven efficacy.
Additionally, please be careful with drug-drug interactions.
Many #COVID19 patients are receiving Lopinavir/Ritonavir.
Many #COVID19 patients are receiving Lopinavir/Ritonavir.
Rito is a very good CYP3A4 inhibitor with some effect on the P-gp as well.
It can boost ivermectin increasing Cmax and potentially penetration on the CNS.
nature.com
It can boost ivermectin increasing Cmax and potentially penetration on the CNS.
nature.com
The new direct effects on the virus reported by Caly and colleagues are very god news!
I understand the urgency. There is reason for hope!
But this required careful planning.
Some trials have already been proposed in the last few weeks.
Watch this space.
I understand the urgency. There is reason for hope!
But this required careful planning.
Some trials have already been proposed in the last few weeks.
Watch this space.
*very goOd
*this requireS
*this requireS
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