Rattibha

Edgar V. Lerma 🇵🇭

12 Tweets 13 reads Jun 04, 2023

Therapeutic Apheresis 101
📌 Extracorporeal procedures whereby blood separation technology is used to remove abnormal blood cells and/or plasma constituents
🔲 Plasmamapheresis
🔲 Leukapheresis
🔲 Erythrocytapheresis
🔲 Thrombocytapheresis
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In plasmapheresis, or therapeutic plasma exchange (TPE), large quantities of plasma are removed from a patient and replaced with
👉🏼 Fresh frozen plasma (FFP), or
👉🏼 Albumin solutions in normal saline
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Comparison of Membrane Plasma Separation and Centrifugal Apheresis #Nephpearls #DialysisDirector

Complications of Plasmapheresis #Nephpearls #DialysisDirector

Strategies to avoid complications during Plasmapheresis
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Plasmapheresis: Choice of Replacement Solution #Nephpearls #DialysisDirector

Plasmapheresis: Vascular Access
📌 Centrifugal Apheresis
👉🏼 BFR 40–50 mL/min
👉🏼 Large peripheral vein (antecubital vein) access
📌 Membrane Plasma Separation
👉🏼 BFR 100-150 mL/min
👉🏼 Central vein access (large bore dual-lumen catheter)
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Plasmapheresis: Albumin
👉🏼 5% albumin solution at a concentration of 5 g/dL (50 g/L) in saline with 130–160 mmol of NaCl per liter can be replaced in a volume equal to that of the removed plasma
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Plasmapheresis: Complications
📌 The most common complication of therapeutic apheresis when using centrifugal machines is related to citrate toxicity
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